As Jesus hung on the cross, suspended between heaven and earth, He uttered several phrases. Of the things He said while death approached, one phrase seems to stand out in its intensity: "My God, My God, why have You forsaken Me?" (Mt. 27:46).
Imagine it. Jesus Christ, who had enjoyed the glories of heaven with the Father for all of eternity past, was now being forsaken. God had turned His back on Him. Abandoned so that He could be our sin-bearer, Jesus cried out in agony.
Those words, "My God, My God," represent Jesus' deeply felt emotions as He suffered there. The personal nature of the pronoun My intensifies the reference to God, as Jesus addressed Him during His suffering.
Contrast Jesus' wrenchingly painful expression with the way the phrase "My God" is tossed around in our society, and you can sense a problem. So often these words are used flippantly and casually. While Jesus said "My God" in an intense reference to the Sovereign of the universe, many people use it as an offhand reference to some mundane experience.
God's name is holy. Use it intensely. Use it boldly. But always use it reverently. — Dave Branon
Words are recorded in heaven,
So be careful what you say;
Take not God's holy name in vain,
But walk with Him day by day. --Shade
If we use God's name loosely, we're taking God too lightly.